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miRNA in epigenetics of rheumatic diseases


Jüngel, A; Gay, S (2011). miRNA in epigenetics of rheumatic diseases. Praxis, 100(1):37-43.

Abstract

Epigenetic modifications are heritable changes in genome function that occur without a change in DNA sequence. They turn genes on or off by small chemical modifications. Thereby, they change the structure of the DNA making them accessible or not for transcription factors or other DNA binding molecules. MicroRNAs are a new class of regulatory non-coding RNAs that modulate gene expression and influences epigenetic mechanisms. miRNAs offer novel mechanisms of therapeutic strategies for cancer and autoimmune diseases. Here, we summarize which miRNAs play a role in rheumatic diseases and their biological function.

Epigenetic modifications are heritable changes in genome function that occur without a change in DNA sequence. They turn genes on or off by small chemical modifications. Thereby, they change the structure of the DNA making them accessible or not for transcription factors or other DNA binding molecules. MicroRNAs are a new class of regulatory non-coding RNAs that modulate gene expression and influences epigenetic mechanisms. miRNAs offer novel mechanisms of therapeutic strategies for cancer and autoimmune diseases. Here, we summarize which miRNAs play a role in rheumatic diseases and their biological function.

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Additional indexing

Other titles:miRNA in der Epigenetik rheumatischer Erkrankungen
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:2011
Deposited On:23 May 2011 14:36
Last Modified:05 Apr 2016 14:55
Publisher:Hans Huber
ISSN:1661-8157
Additional Information:Diese Artikelfassung entspricht nicht vollständig dem in der Zeitschrift veröffentlichten Artikel. Dies ist nicht die Originalversion des Artikels und kann daher nicht zur Zitierung herangezogen werden.
Publisher DOI:10.1024/1661-8157/a00404
PubMed ID:21210359
Permanent URL: http://doi.org/10.5167/uzh-48130

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