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Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease


Distler, J H W; Strapatsas, T; Huscher, D; Dees, C; Akhmetshina, A; Kiener, H P; Tarner, I H; Maurer, B; Walder, M; Michel, B; Gay, S; Smolen, J S; Müller-Ladner, U; Schett, G; Distler, O (2011). Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease. Annals of the Rheumatic Diseases, 70(7):1197-1202.

Abstract

/st> Molecular factors modulating angiogenic responses are dysregulated in patients with MCTD and SSc with increases of VEGF in MCTD and SSc and selective upregulation of endostatin in MCTD. Furthermore, high serum levels of VEGF might characterise patients with MCTD with a more severe course of the disease with increased prevalence of PAH and myositis.

/st> Molecular factors modulating angiogenic responses are dysregulated in patients with MCTD and SSc with increases of VEGF in MCTD and SSc and selective upregulation of endostatin in MCTD. Furthermore, high serum levels of VEGF might characterise patients with MCTD with a more severe course of the disease with increased prevalence of PAH and myositis.

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7 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:06 Jun 2011 13:23
Last Modified:05 Apr 2016 14:55
Publisher:BMJ Publishing Group
ISSN:0003-4967
Publisher DOI:10.1136/ard.2010.140657
PubMed ID:21622771
Permanent URL: http://doi.org/10.5167/uzh-48265

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