Karouzakis, E; Gay, R E; Gay, S; Neidhart, M (2011). Epigenetic deregulation in rheumatoid arthritis. In: Ballestar, E. Epigenetic Contributions in Autoimmune Disease. New York, 137-149. ISBN 978-1-4419-8215-5.
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In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.
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|Item Type:||Book Section, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||20 Jun 2011 11:20|
|Last Modified:||27 Nov 2013 19:34|
|Series Name:||Advances in Experimental Medicine and Biology|
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