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Epigenetic deregulation in rheumatoid arthritis


Karouzakis, E; Gay, R E; Gay, S; Neidhart, M (2011). Epigenetic deregulation in rheumatoid arthritis. In: Ballestar, E. Epigenetic Contributions in Autoimmune Disease. New York: Springer, 137-149.

Abstract

In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.

In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.

Citations

11 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:20 Jun 2011 11:20
Last Modified:05 Apr 2016 14:56
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:711
ISSN:0065-2598
ISBN:978-1-4419-8215-5
Related URLs:http://www.springer.com/biomed/book/978-1-4419-8215-5
PubMed ID:21627047

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