Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Karouzakis, E; Gay, R E; Gay, S; Neidhart, M (2011). Epigenetic deregulation in rheumatoid arthritis. In: Ballestar, E. Epigenetic Contributions in Autoimmune Disease. New York, 137-149. ISBN 978-1-4419-8215-5.

Full text not available from this repository.

Abstract

In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:20 Jun 2011 11:20
Last Modified:27 Nov 2013 19:34
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:711
ISSN:0065-2598
ISBN:978-1-4419-8215-5
Related URLs:http://www.springer.com/biomed/book/978-1-4419-8215-5
PubMed ID:21627047
Citations:Web of Science®. Times Cited: 8
Google Scholar™
Scopus®. Citation Count: 7

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page