Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-48664
Dennler, M; Makara, M; Kranjc, A; Schnyder, M; Ossent, P; Deplazes, P; Ohlerth, S; Glaus, T M (2011). Thoracic computed tomography findings in dogs experimentally infected with Angiostrongylus vasorum. Veterinary Radiology and Ultrasound, 52(3):289-294.
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To characterize the computed tomography (CT) features of thoracic lesions caused by infection with Angiostrongylus
vasorum, pre- and postcontrast CT was performed in six experimentally infected Beagles 13 weeks
postinoculation and in four of these 9 weeks postchemotherapy. Findings were compared with survey radiographs and necropsy findings. A multicentric bronchoalveolar pattern more pronounced at the lung periphery was present radiographically. On CT, the predominant abnormality underlying this alveolar pattern was multiple large nodules merging to areas of consolidation, and containing air bronchograms of varying extent. These nodular changes corresponded to histopathologic granulomata, consisting mainly of macrophages, multinucleated giant cells, and lymphocytes that had accumulated around larvae and eggs. Morphologically, no bronchial changes were observed on CT or histologically. Quantitatively, however, on CT there was evidence of bronchial thickening at 13 weeks postinoculation and mild very peripheral bronchiectasia 9 weeks postchemotherapy.
Regional lymph nodes were enlarged after infection, and smaller after treatment. On postcontrast CT, several
suspicious intraluminal filling defects suggestive of thrombosis were found; however, the tortuosity of some
pulmonary arteries seen radiographically was not present in CT images. After treatment, the consolidations and
large nodules had almost completely disappeared. A remaining radiographic interstitial pattern was characterized on CT as ground-glass opacifications, subpleural interstitial thickening, subpleural lines, and interface signs. These interstitial changes reflected fibrosis as documented histopathologically. CT allowed very detailed and accurate characterization of pulmonary parenchymal lesions, bronchi, and lymphnodes and closely reflected histopathological changes.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Parasitology|
04 Faculty of Medicine > Institute of Parasitology
05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Clinic for Small Animal Internal Medicine
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||14 Jul 2011 13:40|
|Last Modified:||27 Nov 2013 20:52|
|Citations:||Web of Science®. Times Cited: 8|
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