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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-48784

Haybaeck, J; Heikenwalder, M; Klevenz, B; Schwarz, P; Margalith, I; Bridel, C; Mertz, K D; Zirdum, E; Petsch, B; Fuchs, T J; Stitz, L; Aguzzi, A (2011). Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathogens, 7(1):e1001257.

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Abstract

Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to airborne prions. Aerogenic infection occurred also in mice lacking B- and T-lymphocytes, NK-cells, follicular dendritic cells or complement components. Brains of diseased mice contained PrP(Sc) and transmitted scrapie when inoculated into further mice. We conclude that aerogenic exposure to prions is very efficacious and can lead to direct invasion of neural pathways without an obligatory replicative phase in lymphoid organs. This previously unappreciated risk for airborne prion transmission may warrant re-thinking on prion biosafety guidelines in research and diagnostic laboratories.

Citations

22 citations in Web of Science®
26 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:27 Jul 2011 08:28
Last Modified:04 Jul 2016 13:32
Publisher:Public Library of Science (PLoS)
ISSN:1553-7366
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1371/journal.ppat.1001257
PubMed ID:21249178

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