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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-48833

Schoenewolf, N L; Urosevic-Maiwald, M; Dummer, R (2011). Tumour heterogeneity of mucosal melanomas during treatment with imatinib. British Journal of Dermatology, 165(2):419-424.

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Abstract

A comparison of in vitro and in vivo characteristics of tumour cells derived from patients with mucosal melanoma treated with imatinib was performed with respect to KIT mutations. Three patients with mucosal melanoma were treated with imatinib. Patient-derived tumour material was used to establish melanoma cell cultures ex vivo. We evaluated tumour material and cell cultures for KIT protein expression and KIT mutation status. In addition, proliferation assays with melanoma cell cultures were performed with imatinib. Expression of KIT protein and KIT mutation was shown in two patients who responded to imatinib in vivo. Cells derived from a third patient who did not respond to imatinib did not express KIT and lacked a KIT mutation. Patient-derived melanoma cells did not show any KIT mutations, nor did they respond to imatinib in vitro. Our study underlines that melanoma consists of a heterogeneous cell population, making it imperative to use the mapping of involved activating tumour growth-driving pathways in order to improve response to therapy with kinase inhibitors.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:28 Jul 2011 11:08
Last Modified:18 Apr 2014 11:28
Publisher:Wiley-Blackwell
ISSN:0007-0963
Publisher DOI:10.1111/j.1365-2133.2011.10376.x
PubMed ID:21495997
Citations:Web of Science®. Times Cited: 2
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Scopus®. Citation Count: 3

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