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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-49036

Misteli, M; Duschek, S; Richter, A; Grimm , S; Rezk , M; Kraehenmann , R; Boeker , H; Seifritz , E; Schuepbach, D (2011). Gender characteristics of cerebral hemodynamics during complex cognitive functioning. Brain and Cognition, 76(1):123-130.

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Abstract

Functional Transcranial Doppler sonography (fTCD) has been applied to assess peak mean cerebral blood flow velocity (MFV) with a high temporal resolution during cognitive activation. Yet, little attention has been devoted to gender-related alterations of MFV, including spectral analysis. In healthy subjects, fTCD was used to investigate a series of cerebral hemodynamic parameters in the middle cerebral arteries (MCA) during the Trail Making Tests (TMT), a means of selective attention and complex cognitive functioning. In females, there was a frequency peak at 0.375 Hz in both MCA, and we observed a dynamic shift in hemispheric dominance during that condition. Further, after the start phase, there was an MFV decline during complex functioning for the entire sample. These novel results suggest condition-specific features of cerebral hemodynamics in females, and it adds to the notion that gender is a fundamental confounder of brain physiology.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:610 Medicine & health
Uncontrolled Keywords:Attention ; Cerebral blood flow ; Executive function ; Fourier transformation ; Gender ; Transcranial Doppler sonography
Language:English
Date:2011
Deposited On:08 Aug 2011 16:23
Last Modified:27 Nov 2013 20:18
Publisher:Elsevier
ISSN:0278-2626
Funders:Hartmann Müller Foundation for Medical Research
Publisher DOI:10.1016/j.bandc.2011.02.009
PubMed ID:21420774
Citations:Web of Science®. Times Cited: 4
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