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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-49163

Bürge, J; Knechtle, B; Knechtle, P; Gnädinger, M; Rüst, A C; Rosemann, T (2011). Maintained serum sodium in male ultra-marathoners - the role of fluid intake, vasopressin, and aldosterone in fluid and electrolyte regulation. Hormone and Metabolic Research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, 43(9):646-652.

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Abstract

Exercise-associated hyponatremia (EAH) is a well know electrolyte disorder in endurance athletes. Although fluid overload is the most like etiology, recent studies, however, argued whether EAH is a disorder of vasopressin secretion. The aims of the present study were to investigate (i) the prevalence of EAH in male ultra-marathoners and (ii) whether fluid intake, aldosterone or vasopressin, as measured by copeptin, were associated with post-race serum sodium concentration ([Na+]). In 50 male ultra-marathoners in a 100 km ultra-marathon, serum [Na+], aldosterone, copeptin, serum and urine osmolality, and body mass were measured pre- and post-race. Fluid intake, renal function parameters and urine excretion were measured. No athlete developed EAH. Copeptin and aldosterone increased; a significant correlation was found between the change in copeptin and the change in serum [Na+], no correlation was found between aldosterone and serum [Na+]. Serum [Na+] increased by 1.6%; body mass decreased by 1.9 kg. The change in serum [Na+] and body mass correlated significantly and negatively. The fluid intake of ~ 0.58 l/h was positively related to the change in body mass and negatively to both post-race serum [Na+] and the change in serum [Na+]. We conclude that serum [Na+] was maintained by both the mechanisms of fluid intake and the hormonal regulation of vasopressin.

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12 citations in Web of Science®
14 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:22 Aug 2011 06:38
Last Modified:25 Dec 2013 11:31
Publisher:Thieme
ISSN:0018-5043
Additional Information:Copyright: Georg Thieme Verlag
Publisher DOI:10.1055/s-0031-1284352
PubMed ID:21823061

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