Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-49163
Bürge, J; Knechtle, B; Knechtle, P; Gnädinger, M; Rüst, A C; Rosemann, T (2011). Maintained serum sodium in male ultra-marathoners - the role of fluid intake, vasopressin, and aldosterone in fluid and electrolyte regulation. Hormone and Metabolic Research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, 43(9):646-652.
Exercise-associated hyponatremia (EAH) is a well know electrolyte disorder in endurance athletes. Although fluid overload is the most like etiology, recent studies, however, argued whether EAH is a disorder of vasopressin secretion. The aims of the present study were to investigate (i) the prevalence of EAH in male ultra-marathoners and (ii) whether fluid intake, aldosterone or vasopressin, as measured by copeptin, were associated with post-race serum sodium concentration ([Na+]). In 50 male ultra-marathoners in a 100 km ultra-marathon, serum [Na+], aldosterone, copeptin, serum and urine osmolality, and body mass were measured pre- and post-race. Fluid intake, renal function parameters and urine excretion were measured. No athlete developed EAH. Copeptin and aldosterone increased; a significant correlation was found between the change in copeptin and the change in serum [Na+], no correlation was found between aldosterone and serum [Na+]. Serum [Na+] increased by 1.6%; body mass decreased by 1.9 kg. The change in serum [Na+] and body mass correlated significantly and negatively. The fluid intake of ~ 0.58 l/h was positively related to the change in body mass and negatively to both post-race serum [Na+] and the change in serum [Na+]. We conclude that serum [Na+] was maintained by both the mechanisms of fluid intake and the hormonal regulation of vasopressin.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice|
|DDC:||610 Medicine & health|
|Deposited On:||22 Aug 2011 08:38|
|Last Modified:||27 Nov 2013 20:33|
|Additional Information:||Copyright: Georg Thieme Verlag|
|Citations:||Web of Science®. Times cited: 9|
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