Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-49163

Bürge, J; Knechtle, B; Knechtle, P; Gnädinger, M; Rüst, A C; Rosemann, T (2011). Maintained serum sodium in male ultra-marathoners : the role of fluid intake, vasopressin, and aldosterone in fluid and electrolyte regulation. Hormone and Metabolic Research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, 43(9):646-652.

Accepted Version
View at publisher


Exercise-associated hyponatremia (EAH) is a well know electrolyte disorder in endurance athletes. Although fluid overload is the most like etiology, recent studies, however, argued whether EAH is a disorder of vasopressin secretion. The aims of the present study were to investigate (i) the prevalence of EAH in male ultra-marathoners and (ii) whether fluid intake, aldosterone or vasopressin, as measured by copeptin, were associated with post-race serum sodium concentration ([Na+]). In 50 male ultra-marathoners in a 100 km ultra-marathon, serum [Na+], aldosterone, copeptin, serum and urine osmolality, and body mass were measured pre- and post-race. Fluid intake, renal function parameters and urine excretion were measured. No athlete developed EAH. Copeptin and aldosterone increased; a significant correlation was found between the change in copeptin and the change in serum [Na+], no correlation was found between aldosterone and serum [Na+]. Serum [Na+] increased by 1.6%; body mass decreased by 1.9 kg. The change in serum [Na+] and body mass correlated significantly and negatively. The fluid intake of ~ 0.58 l/h was positively related to the change in body mass and negatively to both post-race serum [Na+] and the change in serum [Na+]. We conclude that serum [Na+] was maintained by both the mechanisms of fluid intake and the hormonal regulation of vasopressin.


17 citations in Web of Science®
19 citations in Scopus®
Google Scholar™



84 downloads since deposited on 22 Aug 2011
24 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Aug 2011 06:38
Last Modified:05 Apr 2016 14:58
Additional Information:Copyright: Georg Thieme Verlag
Publisher DOI:10.1055/s-0031-1284352
PubMed ID:21823061

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page