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Cell polarity in fission yeast: A matter of confining, positioning, and switching growth zones


Huisman, S M; Brunner, D (2011). Cell polarity in fission yeast: A matter of confining, positioning, and switching growth zones. Seminars in Cell and Developmental Biology, 22(8):799-805.

Abstract

The two key processes in growth polarisation are the generation of a confined region and the correct positioning of that region. Fission yeast has greatly contributed to the study of cell polarisation, particularly in the aspect of growth site positioning, which involves the interphase microtubule cytoskeleton. Here we review the mechanisms of growth polarity in vegetatively growing fission yeast cells. These seemingly simple cells show astonishingly complex growth polarity behaviour, including polarity switching and integrating multiple levels of control by the cell cycle machinery. We aim to extract and highlight the underlying concepts and discuss these in context of current understanding; showing how relevant proteins are networked to integrate the various machineries.

The two key processes in growth polarisation are the generation of a confined region and the correct positioning of that region. Fission yeast has greatly contributed to the study of cell polarisation, particularly in the aspect of growth site positioning, which involves the interphase microtubule cytoskeleton. Here we review the mechanisms of growth polarity in vegetatively growing fission yeast cells. These seemingly simple cells show astonishingly complex growth polarity behaviour, including polarity switching and integrating multiple levels of control by the cell cycle machinery. We aim to extract and highlight the underlying concepts and discuss these in context of current understanding; showing how relevant proteins are networked to integrate the various machineries.

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15 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:22 July 2011
Deposited On:06 Sep 2011 13:27
Last Modified:05 Apr 2016 14:59
Publisher:Elsevier
ISSN:1084-9521
Publisher DOI:10.1016/j.semcdb.2011.07.013
PubMed ID:21803169
Permanent URL: http://doi.org/10.5167/uzh-49279

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