Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-49282
Aitman, T J; Boone, C; Churchill, G A; Hengartner, M O; Mackay, T F C; Stemple, D L (2011). The future of model organisms in human disease research. Nature Reviews. Genetics, 12(8):575-582.
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Model organisms have played a huge part in the history of studies of human genetic disease, both in identifying disease genes and characterizing their normal and abnormal functions. But is the importance of model organisms diminishing? The direct discovery of disease genes and variants in humans has been revolutionized, first by genome-wide association studies and now by whole-genome sequencing. Not only is it now much easier to directly identify potential disease genes in humans, but the genetic architecture that is being revealed in many cases is hard to replicate in model organisms. Furthermore, disease modelling can be done with increasing effectiveness using human cells. Where does this leave non-human models of disease?
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Deposited On:||06 Sep 2011 13:34|
|Last Modified:||01 Dec 2013 01:56|
|Publisher:||Nature Publishing Group|
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