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The future of model organisms in human disease research


Aitman, T J; Boone, C; Churchill, G A; Hengartner, M O; Mackay, T F C; Stemple, D L (2011). The future of model organisms in human disease research. Nature Reviews. Genetics, 12(8):575-582.

Abstract

Model organisms have played a huge part in the history of studies of human genetic disease, both in identifying disease genes and characterizing their normal and abnormal functions. But is the importance of model organisms diminishing? The direct discovery of disease genes and variants in humans has been revolutionized, first by genome-wide association studies and now by whole-genome sequencing. Not only is it now much easier to directly identify potential disease genes in humans, but the genetic architecture that is being revealed in many cases is hard to replicate in model organisms. Furthermore, disease modelling can be done with increasing effectiveness using human cells. Where does this leave non-human models of disease?

Model organisms have played a huge part in the history of studies of human genetic disease, both in identifying disease genes and characterizing their normal and abnormal functions. But is the importance of model organisms diminishing? The direct discovery of disease genes and variants in humans has been revolutionized, first by genome-wide association studies and now by whole-genome sequencing. Not only is it now much easier to directly identify potential disease genes in humans, but the genetic architecture that is being revealed in many cases is hard to replicate in model organisms. Furthermore, disease modelling can be done with increasing effectiveness using human cells. Where does this leave non-human models of disease?

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2011
Deposited On:06 Sep 2011 13:34
Last Modified:05 Apr 2016 14:59
Publisher:Nature Publishing Group
ISSN:1471-0056
Publisher DOI:https://doi.org/10.1038/nrg3047
PubMed ID:21765459
Permanent URL: https://doi.org/10.5167/uzh-49282

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