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Keck, M E; Ströhle, A (2005). Challenge studies in anxiety disorders. In: Holsboer, F; Ströhle, A. Anxiety and Anxiolytic Drugs. Berlin [etc.]: Springer, 449-468.

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In psychiatry, the use of pharmacological challenges in panic disorder is unique in that the clinical phenomenon of central interest (i.e., the panic attack) can be provoked readily and assessed in the clinical laboratory setting. During the past 20 years pharmacological challenge studies have increased our knowledge concerning the neurobiology of panic disorder remarkably and may ultimately result in novel and more causal treatment strategies. Moreover, the differences in sensitivity to certain panicogens such as serotonergic agents, lactate, carbon dioxide and cholecystokinin tetrapeptide are likely to be fruitful in serving as biological markers of subtypes of panic disorders and should be a major focus of research, as the identification of reliable endophenotypes is currently one of the major rate-limiting steps in psychiatric genetic studies.


Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:05 Sep 2011 09:09
Last Modified:28 Oct 2014 16:00
Series Name:Handbook of Experimental Pharmacology
Related URLs:http://www.springer.com/978-3-540-22568-3
PubMed ID:16594268

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