Coon, K D; Myers, A J; Craig, D W; Webster, J A; Pearson, J V; Lince, D H; Zismann, V L; Beach, T G; Leung, D; Bryden, L; Halperin, R F; Marlowe, L; Kaleem, M; Walker, D G; Ravid, R; Heward, C B; Rogers, J; Papassotiropoulos, A; Reiman, E M; Hardy, J; Stephan, D A (2007). A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. Journal of Clinical Psychiatry, 68(4):613-618.
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This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. It also supports the feasibility of the ultra-high-density whole-genome association approach to the study of AD and other heritable phenotypes. These whole-genome association studies show great promise to identify additional genes that contribute to the risk of AD.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine|
|DDC:||610 Medicine & health|
|Deposited On:||06 Sep 2011 07:49|
|Last Modified:||28 Oct 2014 16:00|
|Publisher:||Physicians Postgraduate Press|
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