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A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease


Coon, K D; Myers, A J; Craig, D W; Webster, J A; Pearson, J V; Lince, D H; Zismann, V L; Beach, T G; Leung, D; Bryden, L; Halperin, R F; Marlowe, L; Kaleem, M; Walker, D G; Ravid, R; Heward, C B; Rogers, J; Papassotiropoulos, A; Reiman, E M; Hardy, J; Stephan, D A (2007). A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. Journal of Clinical Psychiatry, 68(4):613-618.

Abstract

This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. It also supports the feasibility of the ultra-high-density whole-genome association approach to the study of AD and other heritable phenotypes. These whole-genome association studies show great promise to identify additional genes that contribute to the risk of AD.

This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. It also supports the feasibility of the ultra-high-density whole-genome association approach to the study of AD and other heritable phenotypes. These whole-genome association studies show great promise to identify additional genes that contribute to the risk of AD.

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264 citations in Web of Science®
254 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2007
Deposited On:06 Sep 2011 07:49
Last Modified:16 Aug 2016 10:14
Publisher:Physicians Postgraduate Press
ISSN:0160-6689
PubMed ID:17474819

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