Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Coon, K D; Myers, A J; Craig, D W; Webster, J A; Pearson, J V; Lince, D H; Zismann, V L; Beach, T G; Leung, D; Bryden, L; Halperin, R F; Marlowe, L; Kaleem, M; Walker, D G; Ravid, R; Heward, C B; Rogers, J; Papassotiropoulos, A; Reiman, E M; Hardy, J; Stephan, D A (2007). A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. Journal of Clinical Psychiatry, 68(4):613-618.

Full text not available from this repository.

Abstract

This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. It also supports the feasibility of the ultra-high-density whole-genome association approach to the study of AD and other heritable phenotypes. These whole-genome association studies show great promise to identify additional genes that contribute to the risk of AD.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
DDC:610 Medicine & health
Language:English
Date:2007
Deposited On:06 Sep 2011 09:49
Last Modified:27 Nov 2013 22:48
Publisher:Physicians Postgraduate Press
ISSN:0160-6689
PubMed ID:17474819
Citations:Web of Science®. Times Cited: 211
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page