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How specific are deficits in mismatch negativity generation to schizophrenia?


Umbricht, D; Koller, R; Schmid, L; Skrabo, A; Grübel, C; Huber, T; Stassen, H (2003). How specific are deficits in mismatch negativity generation to schizophrenia? Biological Psychiatry, 53(12):1120-1131.

Abstract

Mismatch negativity deficits, and by extension deficits in early cortical auditory information processing, appear to be specific to schizophrenia. Animal and human studies implicate dysfunctional N-methyl-D-aspartate receptor functioning in MMN deficits. Thus MMN deficits may become a useful endophenotype to investigate the genetic underpinnings of schizophrenia, particularly with regard to the N-methyl-D-aspartate receptor.

Mismatch negativity deficits, and by extension deficits in early cortical auditory information processing, appear to be specific to schizophrenia. Animal and human studies implicate dysfunctional N-methyl-D-aspartate receptor functioning in MMN deficits. Thus MMN deficits may become a useful endophenotype to investigate the genetic underpinnings of schizophrenia, particularly with regard to the N-methyl-D-aspartate receptor.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2003
Deposited On:08 Sep 2011 09:26
Last Modified:05 Apr 2016 15:00
Publisher:Elsevier
ISSN:0006-3223
Publisher DOI:10.1016/S0006-3223(02)01642-6
PubMed ID:12814863

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