UZH-Logo

Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins


Koller, M F; Papassotiropoulos, A; Henke, K; Behrends, B; Noda, S; Kratzer, A; Hock, C; Hofmann, M (2005). Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins. Neurodegenerative Diseases, 2(2):56-60.

Abstract

We report two 71-year-old female monozygotic twins presenting with advanced hyperostosis frontalis interna, obesity, shortness and cognitive impairment. They both have suffered from generalized seizures since their early adulthood. Moreover, the patients showed some additional conditions only occurring in one individual or the other such as migraine, marked recurrent depressive disorder or polyarthrosis. The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients.

We report two 71-year-old female monozygotic twins presenting with advanced hyperostosis frontalis interna, obesity, shortness and cognitive impairment. They both have suffered from generalized seizures since their early adulthood. Moreover, the patients showed some additional conditions only occurring in one individual or the other such as migraine, marked recurrent depressive disorder or polyarthrosis. The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients.

Citations

3 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 09 Sep 2011
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2005
Deposited On:09 Sep 2011 14:18
Last Modified:07 Jul 2016 12:17
Publisher:Karger
ISSN:1660-2854
Publisher DOI:10.1159/000089284
PubMed ID:16909048
Permanent URL: http://doi.org/10.5167/uzh-49533

Download

[img]
Preview
Content: Published Version
Filetype: PDF
Size: 192kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations