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Mann, A; Thakur, G; Shukla, V; Ganguli, M (2008). Peptides in DNA delivery: current insights and future directions. Drug Discovery Today, 13(3-4):152-160.

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Abstract

Peptides are emerging as attractive alternatives to cationic polymers and lipids for nonviral DNA delivery. Their remarkable properties such as efficient condensation of DNA, translocation across the cellular membrane, pH-sensitive membrane disruption, and efficient targeting of attached cargoes to the nucleus make them lucrative for researchers to explore their application in DNA delivery. In this review article, we focus on how the chemical nature, structural features and DNA complexation strategies of different peptides have been utilized for efficient DNA delivery. We also discuss their potential problems hindering in vivo application.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:13 Sep 2011 09:22
Last Modified:27 Nov 2013 20:47
Publisher:Elsevier
ISSN:1359-6446
Publisher DOI:10.1016/j.drudis.2007.11.008
PubMed ID:18275913
Citations:Web of Science®. Times Cited: 29
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