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Peptides in DNA delivery: current insights and future directions


Mann, A; Thakur, G; Shukla, V; Ganguli, M (2008). Peptides in DNA delivery: current insights and future directions. Drug Discovery Today, 13(3-4):152-160.

Abstract

Peptides are emerging as attractive alternatives to cationic polymers and lipids for nonviral DNA delivery. Their remarkable properties such as efficient condensation of DNA, translocation across the cellular membrane, pH-sensitive membrane disruption, and efficient targeting of attached cargoes to the nucleus make them lucrative for researchers to explore their application in DNA delivery. In this review article, we focus on how the chemical nature, structural features and DNA complexation strategies of different peptides have been utilized for efficient DNA delivery. We also discuss their potential problems hindering in vivo application.

Peptides are emerging as attractive alternatives to cationic polymers and lipids for nonviral DNA delivery. Their remarkable properties such as efficient condensation of DNA, translocation across the cellular membrane, pH-sensitive membrane disruption, and efficient targeting of attached cargoes to the nucleus make them lucrative for researchers to explore their application in DNA delivery. In this review article, we focus on how the chemical nature, structural features and DNA complexation strategies of different peptides have been utilized for efficient DNA delivery. We also discuss their potential problems hindering in vivo application.

Citations

40 citations in Web of Science®
41 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:13 Sep 2011 07:22
Last Modified:16 Aug 2016 10:13
Publisher:Elsevier
ISSN:1359-6446
Publisher DOI:https://doi.org/10.1016/j.drudis.2007.11.008
PubMed ID:18275913

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