Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive 

Angst, J; Gamma, A; Pezawas, L; Ajdacic-Gross, V; Eich, D; Rössler, W; Altamura, C (2007). Parsing the clinical phenotype of depression: the need to integrate brief depressive episodes. Acta Psychiatrica Scandinavica, 115(3):221-228.

Full text not available from this repository.


OBJECTIVE: To expand the concept of recurrent brief depression (RBD) to brief depression (BD) and to test its clinical relevance. METHOD: Subjects (N = 591) were studied prospectively six times from ages 20/21 to 40/41 years. RBD was defined according to DSM-IV as episodes under 2 weeks with about monthly recurrence and work impairment. BD embraces RBD and brief depressive episodes with a frequency of 1-11 per year. RESULTS: Pure BD and pure major depressive episodes (MDE) did not differ in treatment rates, family history of mood and anxiety disorders or comorbidity with bipolar spectrum and anxiety disorders but they differed in work impairment, suicide attempt rates and distress self-ratings. The combination of BD + MDE identified a very severe group of MDE, comparable with combined depression (MDE + RBD) and double depression (MDE + dysthymia). CONCLUSION: Our data argue for the use of BD as a diagnostic specifier for severe MDE. RBD remains an important independent subgroup.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
DDC:610 Medicine & health
Uncontrolled Keywords:Adult Depressive Disorder, Major/*diagnosis/epidemiology/*psychology Diagnosis, Differential Female Humans Incidence Male Periodicity *Phenotype Prevalence Prospective Studies Questionnaires Switzerland/epidemiology Time Factors
Deposited On:28 Sep 2011 07:46
Last Modified:27 Nov 2013 18:39
Publisher DOI:10.1111/j.1600-0447.2006.00893.x
PubMed ID:17302622
Citations:Web of Science®. Times Cited: 8
Google Scholar™
Scopus®. Citation Count: 9

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page