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Gamma, A; Angst, J; Ajdacic, V; Eich, D; Rössler, W (2007). The spectra of neurasthenia and depression: course, stability and transitions. European Archives of Psychiatry and Clinical Neuroscience, 257(2):120-127.

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BACKGROUND: Neurasthenia has had a chequered history, receiving changing labels such as chronic fatigue or Gulf war syndrome. Neurasthenia is recognized by ICD-10, but not by DSM-IV. Its course, longitudinal stability and relationship to depression is not well understood. METHODS: In a stratified community sample (n = 591), representative of 2600 persons of the canton of Zurich, Switzerland, neurasthenia and depression were assessed in six structured interviews between ages 20 and 41. Course, stability and comorbidity were examined. A severity spectrum of neurasthenia and depression from symptoms to diagnosis was taken into account. RESULTS: The annual prevalence of a neurasthenia diagnosis increased from 0.7% to 3.8% from age 22-41, while mere symptoms became less prevalent. Intraindividual courses improved in 40% and deteriorated in about 30% of symptomatic cases. The most frequent symptoms overall, besides criterial exhaustion, were increased need for sleep, over-sensitivity, nervousness and difficulty concentrating. Cross-sectional associations and overlap with depression were strong. Longitudinal stability of ICD-neurasthenia was low. CONCLUSIONS: Neurasthenia is intermittent, overlaps significantly with depression, and shows improvement and deterioration over time to roughly equal measures.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Adult - Age of Onset - Depression/diagnosis/epidemiology - physiopathology/psychology - Female - Humans - Male - Models, Theoretical - Neurasthenia/diagnosis/epidemiology - /physiopathology/psychology - Predictive Value of Tests - Reproducibility of Results - Severity of Illness Index - Switzerland
Deposited On:28 Sep 2011 10:42
Last Modified:05 Apr 2016 15:01
Publisher DOI:10.1007/s00406-006-0699-6
PubMed ID:17131216

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