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Reutter, H; Boyadjiev, S A; Gambhir, L; Ebert, A K; Rösch, W H; Stein, R; Schröder, A; Boemers, T M; Bartels, E; Vogt, H; Utsch, B; Müller, M; Detlefsen, B; Zwink, N; Rogenhofer, S; Gobet, R; Beckers, G M A; Bökenkamp, A; Kajbafzadeh, A M; Jaureguizar, E; Draaken, M; Lakshmanan, Y; Gearhart, J P; Ludwig, M; Nöthen, M M; Jenetzky, E (2011). Phenotype severity in the bladder exstrophy-epispadias complex: Analysis of genetic and nongenetic contributing factors in 441 families from North America and Europe. Journal of Pediatrics, 159(5):825-831.e1.

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Abstract

OBJECTIVE: To identify genetic and nongenetic risk factors that contribute to the severity of the bladder exstrophy-epispadias complex (BEEC). STUDY DESIGN: Patients with BEEC from North America (n = 167) and Europe (n = 274) were included. The following data were collected: associated anomalies, parental age at conception, mode of conception, periconceptional folic acid supplementation, maternal risk factors during pregnancy, and environmental risk factors. The patients were divided into 3 subgroups according to phenotype severity: (i) mild, epispadias (n = 43); (ii) intermediate, classic bladder exstrophy (n = 366); and (iii) severe, cloacal exstrophy (n = 31). These subgroups then were compared with identify factors that contribute to phenotype severity. RESULTS: Males were overrepresented in all subgroups. A relatively high prevalence of cleft lip, with or without cleft palate, was observed. Maternal smoking and medical radiation during the first trimester were associated with the severe cloacal exstrophy phenotype. Compliance with periconceptional folic acid supplementation was associated with the mildest phenotype (epispadias). CONCLUSIONS: Periconceptional folic acid supplementation appears to prevent the development of the severe phenotype of BEEC.

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6 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:30 Sep 2011 07:46
Last Modified:27 Nov 2013 16:55
Publisher:Elsevier
ISSN:0022-3476
Publisher DOI:10.1016/j.jpeds.2011.04.042
PubMed ID:21679965

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