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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50115

Röösli, C; Linthicum, F H; Cureoglu, S; Merchant, S N (2012). What is the site of origin of cochleovestibular schwannomas. Audiology & Neuro-Otology, 17(2):121-125.

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Abstract

The belief that cochleovestibular schwannomas arise from the glial-Schwann cell junction has repeatedly been quoted in the literature, although there is no published evidence that supports this statement. A systematic evaluation of the nerve of origin and the precise location of cochleovestibular schwannomas using our respective archival temporal bone collections was conducted. Forty tumors were within the internal auditory canal (IAC), while 10 were intralabyrinthine neoplasms. Of the 40 IAC schwannomas, 4 arose from the cochlear nerve, and 36 from the vestibular nerve. Twenty-one tumors clearly arose lateral to the glial-Schwann cell junction, while 16 tumors filled at least two thirds of the IAC, with the epicenter of the neoplasm located in the mid part or the lateral part of the IAC. Only 3 schwannomas were located in the medial one third of the IAC in the area of the glial-Schwann cell junction. We concluded that cochleovestibular schwannomas may arise anywhere along the course of the axons of the eighth cranial nerve from the glial-Schwann sheath junction up until their terminations within the auditory and vestibular end organs.

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6 citations in Web of Science®
6 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:19 Oct 2011 12:10
Last Modified:30 Nov 2013 04:35
Publisher:Karger
ISSN:1420-3030
Publisher DOI:10.1159/000331394
PubMed ID:21968195

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