Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50221
Woodward, T S; Ruff, Christian C; Ngan, E T C (2006). Short- and long-term changes in anterior cingulate activation during resolution of task-set competition. Brain Research, 1068(1):161-169.
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Alternating between task sets involves detection that the current task set is unfavorable, initiation of a change in set, and application of the new task set while fine-tuning to optimally adjust to the demands of the environment. Functional magnetic resonance imaging (fMRI) studies of cognitive flexibility consistently report activation of the anterior cingulate cortex and/or adjacent pre-supplementary motor regions (ACC/pre-SMA, medial Brodmann's areas 24/32/6), suggesting that these cortical regions are involved in switching task set. In the current study, our objective was to probe whether ACC/pre-SMA activation would decrease for a number of trials following a switch in task set, implying longer-term involvement in fine-tuning adjustments. By measuring activation when switching between word reading and color naming in response to Stroop stimuli, ACC/pre-SMA activation was observed when actively countering the influence of the irrelevant task set, and this activation decreased as a function of the number of trials since a task switch. Basal ganglia and thalamic regions also displayed a decreased response over successive trials after task switches. These findings suggest that the ACC/pre-SMA are not only involved in generating a new course of action, but are also involved (along with subcortical regions) in fine-tuning operations that resolve competition between task sets over subsequent repetitions of the same task.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
|Deposited On:||26 Oct 2011 11:30|
|Last Modified:||27 Nov 2013 18:45|
|Citations:||Web of Science®. Times Cited: 19|
Scopus®. Citation Count: 19
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