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Rostral growth of commissural axons requires the cell adhesion molecule MDGA2


Joset, P; Wacker, A; Babey, R; Ingold, E A; Andermatt, I; Stoeckli, E T; Gesemann, M (2011). Rostral growth of commissural axons requires the cell adhesion molecule MDGA2. Neural Development, 6:22.

Abstract

Directed axonal growth of dorsal commissural interneurons requires an elaborate mixture of instructive (guidance) and permissive (outgrowth supporting) molecules. While Wnt and Sonic hedgehog (Shh) signalling pathways have been shown to specify the growth direction of post-crossing commissural axons, our study now provides evidence that homophilic MDGA2 interactions are essential for axonal extension along the longitudinal axis. Interestingly, so far each part of the complex axonal trajectory of commissural axons uses its own set of guidance and growth-promoting molecules, possibly explaining why such a high number of molecules influencing the growth pattern of commissural interneurons has been identified.

Directed axonal growth of dorsal commissural interneurons requires an elaborate mixture of instructive (guidance) and permissive (outgrowth supporting) molecules. While Wnt and Sonic hedgehog (Shh) signalling pathways have been shown to specify the growth direction of post-crossing commissural axons, our study now provides evidence that homophilic MDGA2 interactions are essential for axonal extension along the longitudinal axis. Interestingly, so far each part of the complex axonal trajectory of commissural axons uses its own set of guidance and growth-promoting molecules, possibly explaining why such a high number of molecules influencing the growth pattern of commissural interneurons has been identified.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:floor plate, in ovo RNAi, post-crossing, immunoglobulin superfamily
Language:English
Date:2011
Deposited On:25 Oct 2011 08:33
Last Modified:05 Apr 2016 15:03
Publisher:BioMed Central
ISSN:1749-8104
Publisher DOI:10.1186/1749-8104-6-22
PubMed ID:21542908
Permanent URL: http://doi.org/10.5167/uzh-50227

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