Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5023
Wagner, C A (2008). When proton pumps go sour: Urinary acidification and kidney stones. Kidney International, 73(10):1103-1105.
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| Accepted Version 1097Kb |
Abstract
H(+)-ATPases mediate urinary acidification along the collecting duct, and mutations in their B1 and a4 subunits result in distal renal tubular acidosis. The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Center for Integrative Human Physiology 04 Faculty of Medicine > Institute of Physiology 07 Faculty of Science > Institute of Physiology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | May 2008 |
| Deposited On: | 14 Nov 2008 18:39 |
| Last Modified: | 23 Nov 2012 15:28 |
| Publisher: | Nature Publishing Group |
| ISSN: | 0085-2538 |
| Publisher DOI: | 10.1038/ki.2008.137 |
| PubMed ID: | 18449176 |
| WoS Citation Count: | 1 |
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