Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5023
Wagner, C A (2008). When proton pumps go sour: Urinary acidification and kidney stones. Kidney International, 73(10):1103-1105.
H(+)-ATPases mediate urinary acidification along the collecting duct, and mutations in their B1 and a4 subunits result in distal renal tubular acidosis. The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||14 Nov 2008 18:39|
|Last Modified:||27 Nov 2013 21:41|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times Cited: 2|
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