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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50395

Stephan, K E; Marshall, J C; Penny, W D; Friston, K J; Fink, G R (2007). Interhemispheric integration of visual processing during task-driven lateralization. Journal of Neuroscience, 27(13):3512-3522.

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Abstract

The mechanisms underlying interhemispheric integration (IHI) remain poorly understood, particularly for lateralized cognitive processes. To test competing theories of IHI, we constructed and fitted dynamic causal models to functional magnetic resonance data from two visual tasks that operated on identical stimuli but showed opposite hemispheric dominance. Using a systematic Bayesian model selection procedure, we found that, in the ventral visual stream, which was activated by letter judgments, interhemispheric connections mediated asymmetric information transfer from the nonspecialized right to the specialized left hemisphere when the latter did not have direct access to stimulus information. Notably, this form of IHI did not engage all areas activated by the task but was specific for areas in the lingual and fusiform gyri. In the dorsal stream, activated by spatial judgments, it did not matter which hemisphere received the stimulus: interhemispheric coupling increased bidirectionally, reflecting recruitment of the nonspecialized left hemisphere. Again, not all areas activated by the task were involved in this form of IHI; instead, it was restricted to interactions between areas in the superior parietal gyrus. Overall, our results provide direct neurophysiological evidence, in terms of effective connectivity, for the existence of context-dependent mechanisms of IHI that are implemented by specific visual areas during task-driven lateralization.

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
DDC:170 Ethics
330 Economics
Language:English
Date:2007
Deposited On:31 Oct 2011 11:23
Last Modified:27 Nov 2013 23:02
Publisher:Society for Neuroscience
ISSN:0270-6474
Publisher DOI:10.1523/JNEUROSCI.4766-06.2007
PubMed ID:17392467
Citations:Web of Science®. Times Cited: 72
Google Scholar™
Scopus®. Citation Count: 73

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