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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50397

Manjaly, Z M; Bruning, N; Neufang, S; Stephan, K E; Brieber, S; Marshall, J C; Kamp-Becker, I; Remschmidt, H; Herpertz-Dahlmann, B; Konrad, K; Fink, G R (2007). Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents. NeuroImage, 35(1):283-291.

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Abstract

Previous studies found normal or even superior performance of autistic patients on visuospatial tasks requiring local search, like the Embedded Figures Task (EFT). A well-known interpretation of this is "weak central coherence", i.e. autistic patients may show a reduced general ability to process information in its context and may therefore have a tendency to favour local over global aspects of information processing. An alternative view is that the local processing advantage in the EFT may result from a relative amplification of early perceptual processes which boosts processing of local stimulus properties but does not affect processing of global context. This study used functional magnetic resonance imaging (fMRI) in 12 autistic adolescents (9 Asperger and 3 high-functioning autistic patients) and 12 matched controls to help distinguish, on neurophysiological grounds, between these two accounts of EFT performance in autistic patients. Behaviourally, we found autistic individuals to be unimpaired during the EFT while they were significantly worse at performing a closely matched control task with minimal local search requirements. The fMRI results showed that activations specific for the local search aspects of the EFT were left-lateralised in parietal and premotor areas for the control group (as previously demonstrated for adults), whereas for the patients these activations were found in right primary visual cortex and bilateral extrastriate areas. These results suggest that enhanced local processing in early visual areas, as opposed to impaired processing of global context, is characteristic for performance of the EFT by autistic patients.

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
DDC:170 Ethics
330 Economics
Language:English
Date:2007
Deposited On:31 Oct 2011 11:30
Last Modified:27 Nov 2013 23:34
Publisher:Elsevier
ISSN:1053-8119
Publisher DOI:10.1016/j.neuroimage.2006.11.036
PubMed ID:17240169
Citations:Web of Science®. Times Cited: 67
Google Scholar™
Scopus®. Citation Count: 73

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