Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50402
Kalisch, R; Korenfeld, E; Stephan, K E; Weiskopf, N; Seymour, B; Dolan, R J (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. Journal of Neuroscience, 26(37):9503-9511.
In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS-noUCS memory trace, competing with the initial fear (CS-UCS) memory. Recall of extinction memory and, hence, CR inhibition at later CS encounters is facilitated by contextual stimuli present during extinction training. In line with theoretical predictions derived from animal studies, we show that, after extinction, a CS-evoked engagement of human ventromedial prefrontal cortex (VMPFC) and hippocampus is context dependent, being expressed in an extinction, but not a conditioning, context. Likewise, a positive correlation between VMPFC and hippocampal activity is extinction context dependent. Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||03 Faculty of Economics > Department of Economics|
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
|Deposited On:||31 Oct 2011 12:38|
|Last Modified:||28 Nov 2013 00:52|
|Publisher:||Society for Neuroscience|
|Citations:||Web of Science®. Times cited: 116|
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