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CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms


Schittenhelm, J; Simon, P; Harter, P N; Zachskorn, C; Schlaszus, H; Röttger, F; Winkels, M; Weller, M; Meyermann, R; Mittelbronn, M (2011). CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms. Histopathology, 58(5):739-749.

Abstract

CD133 expression in human CNS neoplasms is independent of the grade of malignancy but strongly correlates with SRBCT morphology. Together with recent findings showing that CD133 is quickly upregulated upon hypoxia and that CD133(-) cells can also exhibit stem cell properties, our data strongly question the suitability of CD133 as a brain tumour stem cell marker in vivo.

CD133 expression in human CNS neoplasms is independent of the grade of malignancy but strongly correlates with SRBCT morphology. Together with recent findings showing that CD133 is quickly upregulated upon hypoxia and that CD133(-) cells can also exhibit stem cell properties, our data strongly question the suitability of CD133 as a brain tumour stem cell marker in vivo.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:04 Nov 2011 08:24
Last Modified:05 Apr 2016 15:04
Publisher:Wiley-Blackwell
ISSN:0309-0167
Publisher DOI:https://doi.org/10.1111/j.1365-2559.2011.03801.x
PubMed ID:21438906
Permanent URL: https://doi.org/10.5167/uzh-50513

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