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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-50516

Tabatabai, G; Weller, M (2011). Glioblastoma stem cells. Cell and Tissue Research, 343(3):459-465.

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Abstract

Glioblastomas are highly malignant primary brain tumors with one of the worst survival rates among all human cancers. With a more profound understanding of the cellular and molecular mechanisms of tumor initiation and acquired resistance to conventional radio- and chemotherapy, novel therapeutic targets might be discovered to optimize therapeutic approaches. In this regard, the identification of a small cellular subpopulation, called glioblastoma stem cell or stem-like cells or glioma-initiating cells or brain tumor propagating cells, has gained attention. In this article, we briefly summarize the current state of knowledge about this tumor cell population and discuss future directions for basic and clinical research.

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29 citations in Web of Science®
29 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:09 Jan 2012 20:43
Last Modified:08 Dec 2013 06:42
Publisher:Springer
ISSN:0302-766X
Publisher DOI:10.1007/s00441-010-1123-0
PubMed ID:21253762

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