Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Tabatabai, G; Wick, W; Weller, M (2011). Stem cell-mediated gene therapies for malignant gliomas: a promising targeted therapeutic approach? Discovery medicine, 11(61):529-536.

Full text not available from this repository.

Abstract

Glioblastomas are aggressive intrinsic brain tumors. The median overall survival does not exceed 15 months despite surgical resection, radiotherapy, and chemotherapy even in selected clinical trial populations. One reason for this poor outcome is the characteristic infiltrative growth pattern of glioblastomas with tumor cells deeply infiltrating into the normal brain parenchyma and thereby escaping surgical debulking and involved-field radiation therapy. Novel therapeutic strategies are urgently needed including those that target disseminated tumor cells, too. In this regard, the application of adult stem cells as cellular vehicles for the delivery of therapeutic molecules has emerged during the last decade as an experimental approach. Adult stem cells with a tropism for gliomas include neural stem and progenitor cells, mesenchymal stem cells, hematopoietic progenitor cells, and endothelial progenitor cells. Importantly, these candidate cellular carriers also localize to sites of hypoxia and invasive tumor borders which are usually not targeted by currently available therapeutic approaches. Stem cell-based therapeutic approaches could therefore help to overcome some of the current limitations of radio- and chemotherapy and may circumvent toxicity to normal resident cells of the central nervous system. The development of neural stem- and progenitor-based therapies is advanced with a currently ongoing phase I clinical study. We review rationale, achievements, and future challenges in this field.

Citations

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:09 Jan 2012 20:48
Last Modified:04 Apr 2012 14:00
Publisher:UNSPECIFIED
ISSN:1539-6509
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.discoverymedicine.com/Ghazaleh-Tabatabai/2011/06/22/stem-cell-mediated-gene-therapies-for-malignant-gliomas-a-promising-targeted-therapeutic-approach/
PubMed ID:21712019

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page