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Neurocognitive function: an emerging surrogate endpoint for neuro-oncology trials


Weller, M (2011). Neurocognitive function: an emerging surrogate endpoint for neuro-oncology trials. Neuro-Oncology, 13(6):565.

Abstract

Pediatric neuro-oncologists are familiar with the challenge that their potentially curative treatments may come at a high price because they may improve survival, but not without developmental delays and persistent neuropsychological sequelae in a significant proportion of patients. The view that the radiological determination of response or stable disease is a sufficient parameter to ascertain that “my patient is doing well” has long been challenged in adult neuro-oncology in the primary CNS lymphoma field as well as in cohorts of brain metastasis patients treated with whole-brain radiotherapy. In contrast, neurocognitive function in malignant glioma patients has traditionally been assumed to roughly reflect the status of …

Pediatric neuro-oncologists are familiar with the challenge that their potentially curative treatments may come at a high price because they may improve survival, but not without developmental delays and persistent neuropsychological sequelae in a significant proportion of patients. The view that the radiological determination of response or stable disease is a sufficient parameter to ascertain that “my patient is doing well” has long been challenged in adult neuro-oncology in the primary CNS lymphoma field as well as in cohorts of brain metastasis patients treated with whole-brain radiotherapy. In contrast, neurocognitive function in malignant glioma patients has traditionally been assumed to roughly reflect the status of …

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Date:2011
Deposited On:10 Nov 2011 11:53
Last Modified:05 Apr 2016 15:04
Publisher:Oxford University Press
ISSN:1522-8517
Additional Information:This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Neuro-Oncology following peer review. The definitive publisher-authenticated version Neuro Oncol (2011) 13 (6): 565 is available online at: http://dx.doi.org/10.1093/neuonc/nor065
Publisher DOI:10.1093/neuonc/nor065
PubMed ID:21636704
Permanent URL: http://doi.org/10.5167/uzh-50518

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