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Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography


Götzinger, E; Pircher, M; Geitzenauer, W; Ahlers, C; Baumann, B; Michels, S; Schmidt-Erfurth, U; Hitzenberger, C K (2008). Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. Optics Express, 16(21):16410-16422.

Abstract

We present a new method for identifying and segmenting the
retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.

We present a new method for identifying and segmenting the
retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.

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109 citations in Web of Science®
124 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:03 Dec 2008 13:23
Last Modified:05 Apr 2016 12:32
Publisher:Optical Society of America (OSA)
ISSN:1094-4087
Publisher DOI:10.1364/OE.16.016410
PubMed ID:18852747
Permanent URL: http://doi.org/10.5167/uzh-5076

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