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Comment la sérologie peut-elle aider à l’établissement du diagnostic des parasites?


Kramme, S; Marti, H; Genton, B; Hatz, C (2011). Comment la sérologie peut-elle aider à l’établissement du diagnostic des parasites? Revue Médicale Suisse, 7(294):995-999.

Abstract

From a technical standpoint the most widely used tests for serology include the ELISA (enzyme linked immunosorbent assay), the IFA (indirect fluorescence assay), and the immunoblot. ELISA tests are widely used as screening assays since they harbor a high sensitivity. The main pitfall of serologies is the frequency of cross-reactions, especially between the different helminths. This is why positive results should be confirmed by a second test method with a higher specificity. Results need also to be put in the perspective of the patient history, clinical signs and laboratory findings. Serological tests are most appropriate when the parasite cannot be documented by direct examination (by eye or under the microscope) and during the pre-patent period. Serologies for parasites are also useful when an unexplained eosinophilia is present.

From a technical standpoint the most widely used tests for serology include the ELISA (enzyme linked immunosorbent assay), the IFA (indirect fluorescence assay), and the immunoblot. ELISA tests are widely used as screening assays since they harbor a high sensitivity. The main pitfall of serologies is the frequency of cross-reactions, especially between the different helminths. This is why positive results should be confirmed by a second test method with a higher specificity. Results need also to be put in the perspective of the patient history, clinical signs and laboratory findings. Serological tests are most appropriate when the parasite cannot be documented by direct examination (by eye or under the microscope) and during the pre-patent period. Serologies for parasites are also useful when an unexplained eosinophilia is present.

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Additional indexing

Other titles:How can serology contribute to the diagnosis of parasitic diseases?
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:French
Date:2011
Deposited On:11 Nov 2011 09:47
Last Modified:05 Apr 2016 15:05
Publisher:Médecine et Hygiène
ISSN:1660-9379
Official URL:http://rms.medhyg.ch/resume.php?ID_ARTICLE=RMS_294_0995
PubMed ID:21692312

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