Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-509
Dübendorfer, A; Hediger, M; Burghardt, G; Bopp, D (2002). Musca domestica, a window on the evolution of sex-determining mechanisms in insects. International Journal of Developmental Biology, 46(1):75-79.
The genetic cascades regulating sex determination of the housefly, Musca domestica, and the fruitfly, Drosophila melanogaster, appear strikingly different. The bifunctional switch gene doublesex, however, is present at the bottom of the regulatory cascades of both species, and so is transformer-2, one of the genetic elements required for the sex-specific regulation of doublesex. The upstream regulators are different: Drosophila utilizes Sex-lethal to coordinate the control of sex determination and dosage compensation, i.e., the process that equilibrates the difference of two X chromosomes in females versus one X chromosome in males. In the housefly, Sex-lethal is not involved in sex determination, and dosage compensation, if existent at all, is not coupled with sexual differentiation. This allows for more adaptive plasticity in the housefly system. Accordingly, natural housefly populations can vary greatly in their mechanism of sex determination, and new types can be generated in the laboratory.
62 downloads since deposited on 11 Feb 2008
14 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||1 January 2002|
|Deposited On:||11 Feb 2008 12:15|
|Last Modified:||27 Nov 2013 22:07|
|Publisher:||University of the Basque Country Press (UBC Press)|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page