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Cerebrospinal fluid hypocretin-1 levels during the active period of cluster headache


Cevoli, S; Pizza, F; Grimaldi, D; Nicodemo, M; Favoni, V; Pierangeli, G; Valko, P O; Baumann, C R; Montagna, P; Bassetti, C L; Cortelli, P (2011). Cerebrospinal fluid hypocretin-1 levels during the active period of cluster headache. Cephalalgia, 31(8):973-976.

Abstract

BACKGROUND:

Hypocretins (orexins) are hypothalamic neuropeptides which are involved in a wide range of physiological processes in mammals including central pain processing. Genetic studies in humans evidenced a role for the hypocretinergic system in cluster headache (CH).
PATIENTS AND METHODS:

We tested cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) levels in 10 CH patients during an active cluster period. CSF hypocretin-1 levels were measured by radioimmunoassay.
RESULTS:

CSF hypocretin-1 levels were within the normal range (mean 457.3±104.98 pg/ml, range 304-639) in our 10 patients, with a slight reduction in one case (304 pg/ml). There were no associations between CSF hypocretin-1 levels and the clinical features of CH. A trend towards higher hypocretin-1 levels was disclosed in patients with chronic CH compared to episodic CH.
CONCLUSIONS:

CSF hypocretin-1 levels seem not to influence the clinical course of CH, but our results cannot completely exclude a functional involvement of the hypothalamic hypocretinergic system in the pathogenesis of CH.

BACKGROUND:

Hypocretins (orexins) are hypothalamic neuropeptides which are involved in a wide range of physiological processes in mammals including central pain processing. Genetic studies in humans evidenced a role for the hypocretinergic system in cluster headache (CH).
PATIENTS AND METHODS:

We tested cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) levels in 10 CH patients during an active cluster period. CSF hypocretin-1 levels were measured by radioimmunoassay.
RESULTS:

CSF hypocretin-1 levels were within the normal range (mean 457.3±104.98 pg/ml, range 304-639) in our 10 patients, with a slight reduction in one case (304 pg/ml). There were no associations between CSF hypocretin-1 levels and the clinical features of CH. A trend towards higher hypocretin-1 levels was disclosed in patients with chronic CH compared to episodic CH.
CONCLUSIONS:

CSF hypocretin-1 levels seem not to influence the clinical course of CH, but our results cannot completely exclude a functional involvement of the hypothalamic hypocretinergic system in the pathogenesis of CH.

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5 citations in Web of Science®
7 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:14 Jan 2012 17:39
Last Modified:05 Apr 2016 15:05
Publisher:Wiley-Blackwell
ISSN:0333-1024
Publisher DOI:https://doi.org/10.1177/0333102411403634
PubMed ID:21444644
Permanent URL: https://doi.org/10.5167/uzh-50906

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