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Donati, O F; Nordmeyer-Massner, J; Nanz, D; White, L M; Tami, I; Vich, M; Pruessmann, K P; Andreisek, G (2011). Direct MR arthrography of cadaveric wrists: Comparison between MR imaging at 3.0T and 7.0T and gross pathologic inspection. Journal of Magnetic Resonance Imaging, 34(6):1333-1340.

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Abstract

PURPOSE: To prospectively evaluate the diagnostic accuracy of magnetic resonance (MR) arthrography for the detection of articular cartilage abnormalities at 3.0T and 7.0T in cadaveric wrists. MATERIALS AND METHODS: MR imaging (MRI) was performed in nine cadaveric wrists (four right wrists, five left; mean age, 81.0 ± 9.8 years) after the intraarticular administration of gadoterate-meglumine. A 3.0T and 7.0T MR system, mechanically identical custom-built 8-channel wrist coil arrays and a similar standard MRI protocol, were used. MR images were evaluated for visibility of articular cartilage surfaces, presence of cartilage lesions, and confidence of diagnosis by two independent radiologists. Open pathologic inspection served as reference standard. Sensitivity, specificity, negative predictive values (NPV) and positive predictive values (PPV), and accuracy (ACC) were calculated. Wilcoxon signed rank test was used to assess differences in the diagnostic performance. RESULTS: Visibility of articular cartilage surfaces was significantly better at 3.0T than at 7.0T (P < 0.001). Mean sensitivity, specificity, NPV, PPV, ACC for both readers were 63%, 90%, 85%, 76%, 82% at 3.0T, respectively, and 52%, 91%, 82%, 75%, 79% at 7.0T. The difference between 3.0T and 7.0T was not significant for reader 1 (P = 0.51), but was significant for reader 2 (P = 0.01). The level of confidence was significantly higher at 3.0T than at 7.0T for both readers (P = 0.004; P = 0.03). CONCLUSION: MR arthrography of the wrist at 7.0T is still limited by the lack of commercially available radiofrequency coils and limited experience in sequence optimization, resulting in a significantly lower visibility of anatomy, lower diagnostic accuracy, and level of confidence in judging cartilage lesions compared to 3.0T. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:570 Life sciences; biology
170 Ethics
610 Medicine & health
Language:English
Date:2011
Deposited On:17 Nov 2011 08:47
Last Modified:27 Nov 2013 16:34
Publisher:Wiley-Blackwell
ISSN:1053-1807
Publisher DOI:10.1002/jmri.22781
PubMed ID:21953599
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 2

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