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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-51058

Bramlage, C P; Müller, G A; Tampe, B; Bevanda, J; Maatouk, I; Koziolek, M; Lange, K; Ahrens, K; Schmid, H; Cohen, C D; Bramlage, P; Kretzler, M; Strutz, F (2011). The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. Journal of Nephrology, 24(5):647-654.

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Abstract

Background: Bone morphogenetic protein-5 (BMP-5) has been shown to be essential for nephrogenesis. Its role in adult kidney and in patients with hypertensive nephrosclerosis is still unknown. Methods: BMP-5 expression was evaluated by immunostaining and real-time PCR in tissue samples from normal and nephrosclerotic human kidneys. The impact of transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) and angiotensin-II (AT-II) on expression of BMP-5 and its receptors was quantified in proximal tubular cells (HK-2). Functional characteristics of BMP-5 were evaluated by testing its influence on TGF-β–induced epithelial-to-mesenchymal transition (EMT), TNF-α–induced apoptosis of HK-2 cells and inflammatory cell infiltration. Results: BMP-5 expression was localized in tubular epithelial cells and significantly decreased in nephrosclerotic kidneys. Stimulation of HK-2 cells with TGF-β, TNF-α and AT-II resulted in a significant decreased expression of BMP-5 and its receptors. BMP-5 attenuated TGF-β–induced EMT, TNF-α–induced apoptosis and migration of mononuclear cells. Conclusions: BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:17 Nov 2011 10:17
Last Modified:06 Dec 2013 13:47
Publisher:Wichtig Editore
ISSN:1121-8428
Publisher DOI:10.5301/JN.2011.6330
PubMed ID:21319131

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