Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-51123
Yiu, K H; de Graaf, F R; Schuijf, J D; van Werkhoven, J M; van Velzen, J E; Boogers, M J; Roos, C J; de Bie, M K; Pazhenkottil, A; Kroft, L J; Boersma, E; Herzog, B; de Roos, A; Kaufmann, P A; Bax, J J; Jukema, J W (2011). Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography. American Journal of Cardiology, 108(7):968-972.
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Chronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 patients) based on a cut-off estimated glomerular filtration rate of 60 ml/min/1.73 m(2). After 896 days of follow-up, 42 patients developed CV events. Annualized CV event rates were 1.2% in patients with no CKD and no CAD, 2.5% in patients with moderate CKD alone, 2.5% in patients with obstructive CAD alone, and 3.7% in those with moderate CKD and obstructive CAD. Multivariate models demonstrated that moderate CKD (hazard ratio 2.39, confidence interval 1.09 to 5.21, p = 0.03) and obstructive CAD (hazard ratio 2.76, confidence interval 1.40 to 5.44, p <0.01) were independent predictors of CV events. Importantly, moderate CKD provided incremental prognostic information in addition to clinical characteristics and obstructive CAD (chi-square 49.4, p = 0.04). In conclusion, moderate CKD was associated with CV events and provided incremental prognostic information.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||01 October 2011|
|Deposited On:||17 Nov 2011 16:18|
|Last Modified:||02 Dec 2013 05:59|
|Citations:||Web of Science®. Times Cited: 3|
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