Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-51131
Buechel, R R; Pazhenkottil, A P; Herzog, B A; Brueckner, M; Nkoulou, R; Ghadri, J R; Küest, S M; Wyss, C A; Husmann, L; Kaufmann, P A (2011). Prognostic performance of low-dose coronary CT angiography with prospective ECG triggering. Heart, 97(17):1385-1390.
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Objective To assess the prognostic value of low-dose 64-slice coronary CT angiography (CCTA) using prospective ECG triggering in a patient population with known or suspected coronary artery disease (CAD).
Design Longitudinal follow-up study.
Setting Tertiary referral cardiac imaging centre.
Patients 434 consecutive patients who were referred for evaluation of CAD by CCTA.
Methods The presence, distribution and severity of coronary lesions (non-obstructive <50% vs obstructive ≥50% luminal narrowing) were recorded by low-dose prospective ECG-triggered CCTA for each patient. The prognostic value of low-dose CCTA to predict major adverse cardiac events, defined as cardiac death, non-fatal myocardial infarction, or the need for revascularisation, was assessed using multivariate Cox regression analysis. Each person was followed up by telephone interviews and/or on the basis of clinical records. Thirty-eight early revascularised patients were excluded from outcome analysis.
Results Completely normal coronary arteries were documented in 171 patients (47%), while exclusively non-obstructive lesions were found in 66 (18%), and obstructive coronary lesions were diagnosed in 130 patients (35%). A mean follow-up of 47±16 weeks was obtained. The first-year event rate was 0% in patients with normal coronary arteries on CCTA but increased to 3% and 26% in patients with non-obstructive and obstructive coronary artery lesions, respectively. In multivariate Cox regression analysis, a significant predictor of events was the presence of obstructive or any coronary lesions. Mean effective radiation dose was 1.8±0.6 mSv.
Conclusions These data document an excellent prognostic performance of low-dose CCTA.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||17 Nov 2011 11:26|
|Last Modified:||09 Dec 2013 00:46|
|Publisher:||BMJ Publishing Group|
|Citations:||Web of Science®. Times cited: 4|
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