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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-51140

Kuhn, M; Szklarczyk, D; Franceschini, A; von Mering, C; Jensen, L J; Bork, P (2011). STITCH 3: zooming in on protein-chemical interactions. Nucleic Acids Research:Online.

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To facilitate the study of interactions between proteins and chemicals, we have created STITCH, an aggregated database of interactions connecting over 300 000 chemicals and 2.6 million proteins from 1133 organisms. Compared to the previous version, the number of chemicals with interactions and the number of high-confidence interactions both increase 4-fold. The database can be accessed interactively through a web interface, displaying interactions in an integrated network view. It is also available for computational studies through downloadable files and an API. As an extension in the current version, we offer the option to switch between two levels of detail, namely whether stereoisomers of a given compound are shown as a merged entity or as separate entities. Separate display of stereoisomers is necessary, for example, for carbohydrates and chiral drugs. Combining the isomers increases the coverage, as interaction databases and publications found through text mining will often refer to compounds without specifying the stereoisomer. The database is accessible at http://stitch.embl.de/.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
08 University Research Priority Programs > Systems Biology / Functional Genomics
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:18 Nov 2011 09:43
Last Modified:27 Nov 2013 16:55
Publisher:Oxford University Press
Publisher DOI:10.1093/nar/gkr1011
PubMed ID:22075997

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