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CT and MR imaging of hepatocellular carcinoma


Bolog, N; Andreisek, G; Oancea, I; Mangrau, A (2011). CT and MR imaging of hepatocellular carcinoma. Journal of Gastrointestinal and Liver Diseases, 20(2):181-189.

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common tumor in the world and the incidence is expected to increase in the future due to hepatitis viral infections and increasing cirrhosis incidence. The diagnosis of HCC is no longer based on biopsy especially in cases when curative treatment is possible. The imaging criteria are usually based on the vascular findings of HCC (e.g. early arterial uptake followed by washout in the portovenous and equilibrium phase). However, there are several limitations of the assessment of HCC by using only the vascular criteria. The use of tissue-specific contrast agents, including superparamagnetic iron oxides and hepatobiliary contrast agents, improves lesion detection and characterization. Therefore, an accurate diagnosis of HCC implies, at this moment, a combination of vascular and cellular information. This review focuses on the most important findings provided by the unenhanced and dynamic-enhanced CT and MR images regarding HCC evaluation. We also discuss the various imaging characteristics of HCC at MR imaging after the administration of tissue specific contrast agents.

Hepatocellular carcinoma (HCC) is the fifth most common tumor in the world and the incidence is expected to increase in the future due to hepatitis viral infections and increasing cirrhosis incidence. The diagnosis of HCC is no longer based on biopsy especially in cases when curative treatment is possible. The imaging criteria are usually based on the vascular findings of HCC (e.g. early arterial uptake followed by washout in the portovenous and equilibrium phase). However, there are several limitations of the assessment of HCC by using only the vascular criteria. The use of tissue-specific contrast agents, including superparamagnetic iron oxides and hepatobiliary contrast agents, improves lesion detection and characterization. Therefore, an accurate diagnosis of HCC implies, at this moment, a combination of vascular and cellular information. This review focuses on the most important findings provided by the unenhanced and dynamic-enhanced CT and MR images regarding HCC evaluation. We also discuss the various imaging characteristics of HCC at MR imaging after the administration of tissue specific contrast agents.

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13 citations in Web of Science®
23 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:21 Nov 2011 13:34
Last Modified:05 Apr 2016 15:07
Publisher:"Universitatea de Medicina si Farmacie ""Iuliu Hatieganu"""
ISSN:1841-8724
PubMed ID:21725516
Permanent URL: https://doi.org/10.5167/uzh-51213

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