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Husarik, D B; Boll, D T; Nelson, R C; Merkle, E M (2011). Low-dose unenhanced CT for IV contrast bolus timing: is it reliable to assess hepatic steatosis? Academic Radiology, 18(7):822-827.

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Abstract

RATIONALE AND OBJECTIVES: To determine whether an unenhanced low-dose image acquired during automated contrast bolus timing can be used to assess hepatic steatosis. MATERIALS AND METHODS: Fifty subjects (29 male, 21 female; 26-92 years; mean body mass index (BMI; 26.9) with abdominal multiphasic computed tomography were included. Abdominal diameters and circumferences were derived from anteroposterior and lateral scout radiographs. Hepatic attenuation (HA) was measured on unenhanced low-dose images (120 kV; 40 mA; 0.5 seconds' rotation time) and corresponding unenhanced standard-dose images (120 kV, z-axis automatic tube current modulation, noise index 11.5). Noise estimates were measured in surrounding air. Pearson correlation was calculated between abdominal circumference and BMI. Mean HA assessed on low-dose images and standard-dose images was compared using a paired Student's t-test and Bland Altman plots. RESULTS: Abdominal circumference (mean, 142.8cm) correlated well with BMI (r = 0.83). No significant difference was found for HA on low-dose images (mean +57.7 HU) compared to HA on standard-dose images (+56.0 HU) (P = .077). Image noise (+11.5 HU) was significantly higher on low-dose images compared to image noise (+8.1 HU) on standard-dose images (P < .05). For HA mean difference comparing low- and standard-dose images was -1.7 HU (limits of agreement: -14.6, 11.2). CONCLUSION: In all subjects, hepatic attenuation can be correctly assessed on unenhanced low-dose images.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:21 Nov 2011 14:54
Last Modified:28 Nov 2013 02:28
Publisher:Elsevier
ISSN:1076-6332
Publisher DOI:10.1016/j.acra.2011.02.013
PubMed ID:21530330
Citations:Web of Science®
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