Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-51309
Schmid, M A; Takizawa, H; Baumjohann, D R; Saito, Y; Manz, M G (2011). Bone marrow dendritic cell progenitors sense pathogens via toll-like receptors and subsequently migrate to inflamed lymph nodes. Blood, 118(18):4829-4840.
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Common dendritic cell progenitors (CDPs) in the bone marrow (BM) regenerate dendritic cells (DCs) in lymphoid and nonlymphoid tissues. How the dissemination of progenitor-derived DCs to peripheral tissues is regulated on need remains elusive. Microbes are sensed by pathogen recognition receptors such as Toll-like receptors (TLRs). We found that CDPs in the BM express TLR2, TLR4, and TLR9. On TLR stimulation, CDPs down-regulated CXCR4, the nonredundant chemokine receptor for their BM retention, up-regulated CCR7, and migrated to lymph nodes (LNs). When TLR agonists were injected locally, CDPs preferentially gave rise to DCs in inflamed LNs in expense of noninflamed LNs and the BM, but they did not alter their lineage differentiation and proliferative activity. Consequently, BM DC progenitors can sense TLR agonists and, via regulation of CXCR4 and CCR7, support the replenishment of DCs in reactive LNs. This mechanism likely developed to support DC homeostasis on specific need at sites of inflammation.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology|
|Dewey Decimal Classification:||610 Medicine & health|
|Date:||3 November 2011|
|Deposited On:||25 Nov 2011 11:56|
|Last Modified:||22 Dec 2013 01:35|
|Publisher:||American Society of Hematology|
|Additional Information:||This research was originally published in Blood, 118(18):4829-4840. Copyright by the American Society of Hematology|
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