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Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement


Willinger, T; Rongvaux, A; Strowig, T; Manz, M G; Flavell, R A (2011). Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends in Immunology, 32(7):321-327.

Abstract

Human hemato-lymphoid-system mice hold great promise for modeling and studying important human diseases in vivo, and to enable vaccine testing. Until now, several major limitations have restricted the utility of human hemato-lymphoid-system mice in translational research. Recently, however, significant advances have been made in improving these mice, based on the delivery of human cytokines to create a better environment for human cells in the mouse host. In this review, we discuss the various approaches with a particular focus on improving human hemato-lymphoid-system mice by human cytokine knock-in gene replacement.

Human hemato-lymphoid-system mice hold great promise for modeling and studying important human diseases in vivo, and to enable vaccine testing. Until now, several major limitations have restricted the utility of human hemato-lymphoid-system mice in translational research. Recently, however, significant advances have been made in improving these mice, based on the delivery of human cytokines to create a better environment for human cells in the mouse host. In this review, we discuss the various approaches with a particular focus on improving human hemato-lymphoid-system mice by human cytokine knock-in gene replacement.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2011
Deposited On:25 Nov 2011 12:15
Last Modified:05 Apr 2016 15:07
Publisher:Elsevier
ISSN:1471-4906
Publisher DOI:https://doi.org/10.1016/j.it.2011.04.005
PubMed ID:21697012

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