Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-515
Steinmann-Zwicky, M; Nöthiger, R (1985). A small region on the X chromosome of Drosophila regulates a key gene that controls sex determination and dosage compensation. Cell, 42(3):877-887.
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In Drosophila, flies with two X chromosomes are females, with one X chromosome, males. We investigated the presence of sex determining factors on the X chromosome by constructing genotypes with one X and various X-chromosomal duplications. We found that female determining factors are not evenly distributed along the X chromosome as had been previously postulated. A distal duplication covering 35% of the X chromosome promotes female differentiation, a much larger proximal duplication of 60% results in male differentiation. The strong feminizing effect of distal duplications originates from a small segment that, when present in two doses, activates Sxl, a key gene for sex determination and dosage compensation. Our results suggest that Sxl can be activated to intermediate levels.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||1 October 1985|
|Deposited On:||11 Feb 2008 12:15|
|Last Modified:||27 Nov 2013 22:18|
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