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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-515

Steinmann-Zwicky, M; Nöthiger, R (1985). A small region on the X chromosome of Drosophila regulates a key gene that controls sex determination and dosage compensation. Cell, 42(3):877-887.

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In Drosophila, flies with two X chromosomes are females, with one X chromosome, males. We investigated the presence of sex determining factors on the X chromosome by constructing genotypes with one X and various X-chromosomal duplications. We found that female determining factors are not evenly distributed along the X chromosome as had been previously postulated. A distal duplication covering 35% of the X chromosome promotes female differentiation, a much larger proximal duplication of 60% results in male differentiation. The strong feminizing effect of distal duplications originates from a small segment that, when present in two doses, activates Sxl, a key gene for sex determination and dosage compensation. Our results suggest that Sxl can be activated to intermediate levels.


19 citations in Web of Science®
6 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:1 October 1985
Deposited On:11 Feb 2008 12:15
Last Modified:27 Nov 2013 22:18
Publisher DOI:10.1016/0092-8674(85)90284-3
PubMed ID:3931920

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