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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-519

Steinmann-Zwicky, M (1993). Sex determination in Drosophila: sis-b, a major numerator element of the X:A ratio in the soma, does not contribute to the X:A ratio in the germ line. Development, 117(2):763-767.



In soma and germ cells of Drosophila, the X:A ratio builds a primary signal for sex determination, and in both tissues Sex-lethal (Sxl) function is required for cells to enter the female pathway. In somatic cells of XX animals, the products of X-chromosomal elements of the X:A ratio activate Sxl. Here I show that sisterless-b (sis-b), which is the X-chromosomal element of the somatic X:A ratio that has best been analysed, is not required for oogenesis. I also present evidence that Sxl function might not be sufficient to direct germ cells into the female pathway. These results show that the elements forming the X:A ratio in the germ line are different from the elements forming the X:A ratio in the soma and they suggest that, in the germ line, Sxl might not be regulated by the X:A ratio.


38 citations in Web of Science®
24 citations in Scopus®
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63 downloads since deposited on 11 Feb 2008
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:1 February 1993
Deposited On:11 Feb 2008 12:15
Last Modified:05 Apr 2016 12:14
Publisher:Company of Biologists
Related URLs:http://dev.biologists.org/cgi/content/abstract/117/2/763
PubMed ID:8330539

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