Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-52506
Franklin, T B; Linder, N; Russig, H; Thöny, B; Mansuy, I M (2011). Influence of early stress on social abilities and serotonergic functions across generations in mice. PLoS ONE, 6(7):e21842.
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Exposure to adverse environments during early development is a known risk factor for several psychiatric conditions including antisocial behavior and personality disorders. Here, we induced social anxiety and altered social recognition memory in adult mice using unpredictable maternal separation and maternal stress during early postnatal life. We show that these social defects are not only pronounced in the animals directly subjected to stress, but are also transmitted to their offspring across two generations. The defects are associated with impaired serotonergic signaling, in particular, reduced 5HT1A receptor expression in the dorsal raphe nucleus, and increased serotonin level in a dorsal raphe projection area. These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Brain Research Institute
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||04 Jan 2012 16:24|
|Last Modified:||12 Nov 2014 12:24|
|Publisher:||Public Library of Science (PLoS)|
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