Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5268
Eloranta, J J; Kullak-Ublick, G A (2008). The role of FXR in disorders of bile acid homeostasis. Physiology, 23:286-295.
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Abstract
As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology 04 Faculty of Medicine > Center for Integrative Human Physiology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 2008 |
| Deposited On: | 11 Nov 2008 08:47 |
| Last Modified: | 23 Nov 2012 16:29 |
| Publisher: | American Physiological Society |
| ISSN: | 1548-9221 |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | 10.1152/physiol.00020.2008 |
| PubMed ID: | 18927204 |
| WoS Citation Count: | 23 |
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