Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-52843

Dettmer, M; Schmitt, A; Steinert, H; Haldemann, A; Meili, A; Moch, H; Komminoth, P; Perren, A (2011). Poorly differentiated thyroid carcinomas: How much poorly differentiated is needed? American Journal of Surgical Pathology, 35(12):1866-1872.

[img]Published Version
PDF - Registered users only
540kB

View at publisher

Abstract

BACKGROUND: Poorly differentiated (PD) carcinomas of the thyroid are conceptually situated between well-differentiated (papillary or follicular) carcinomas and anaplastic thyroid carcinomas. Although the morphologic criteria for PD tumors are well defined, it is not clear how much of a PD area besides a well-differentiated component in a given tumor is required to allow such a diagnosis.
METHODS: We identified 42 patients suffering from thyroid carcinoma with an adverse clinical outcome. Fifty patients with follicular carcinoma were added as controls. We analyzed poorly differentiated areas by applying the Turin criteria of PD carcinomas. These criteria consisted of the presence of a solid/trabecular/insular growth pattern, lack of nuclear features of papillary carcinoma, and presence of 1 of the following features: (1) convoluted nuclei, (2) tumor necrosis, (3) 3 or more mitoses per 10 high-power fields.
RESULTS: Using a cutoff value of 10% of PD areas per examined tumor surface, we identified a total of 35 PD carcinomas. Despite using a threshold of 10% of the tumor area as poorly differentiated, the survival data in a Kaplan-Meier analysis were significantly worse than those in the control group (P<0.001) and did not differ from tumors with a PD area >50%. In a multivariate analysis that included age, sex, tumor stage, and PD area >10% against survival data, the only consistent significant factor was PD differentiation (P<0.001).
CONCLUSIONS: As even slight amounts of PD areas (≥ 10%) in a thyroid carcinoma affect the prognosis significantly, the presence of such areas may be worth reporting in thyroid carcinomas.

Citations

9 citations in Web of Science®
13 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 04 Jan 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:04 Jan 2012 10:00
Last Modified:20 Dec 2013 05:23
Publisher:Lippincott Wiliams & Wilkins
ISSN:0147-5185
Publisher DOI:10.1097/PAS.0b013e31822cf962
PubMed ID:21989341

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page