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Decrease in VEGF expression induces intussusceptive vascular pruning


Hlushchuk, R; Ehrbar, M; Reichmuth, P; Heinimann, N; Styp-Rekowska, B; Escher, R; Baum, O; Lienemann, P; Makanya, A; Keshet, E; Djonov, V (2011). Decrease in VEGF expression induces intussusceptive vascular pruning. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(12):2836-2844.

Abstract

Diminution of VEGF level induces vascular tree regression by intussusceptive vascular pruning. This observation may allude to the mechanism underlying the "normalization" of tumor vasculature if treated with antiangiogenic drugs. The mechanism described here gives new insights into the understanding of the processes of vasculature regression and hence provides new and potentially viable targets for antiangiogenic and/or angio-modulating therapies during various pathological processes.

Diminution of VEGF level induces vascular tree regression by intussusceptive vascular pruning. This observation may allude to the mechanism underlying the "normalization" of tumor vasculature if treated with antiangiogenic drugs. The mechanism described here gives new insights into the understanding of the processes of vasculature regression and hence provides new and potentially viable targets for antiangiogenic and/or angio-modulating therapies during various pathological processes.

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13 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:06 Jan 2012 13:11
Last Modified:05 Apr 2016 15:14
Publisher:Lippincott Wiliams & Wilkins
ISSN:1079-5642
Publisher DOI:10.1161/ATVBAHA.111.231811
PubMed ID:21921259
Permanent URL: http://doi.org/10.5167/uzh-52933

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