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Myeloid related proteins activate toll-like receptor 4 in human acute coronary syndromes


Yonekawa, K; Neidhart, M; Altwegg, L A; Wyss, C A; Corti, R; Vogl, T; Grigorian, M; Gay, S; Lüscher, T F; Maier, W (2011). Myeloid related proteins activate toll-like receptor 4 in human acute coronary syndromes. Atherosclerosis, 218(2):486-492.

Abstract

In ACS, MRP8 and MRP8/14 complex are specific ligands of TLR4, which induce the release of TNFα and probably other pro-inflammatory agents from monocytes. This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.

In ACS, MRP8 and MRP8/14 complex are specific ligands of TLR4, which induce the release of TNFα and probably other pro-inflammatory agents from monocytes. This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.

Citations

27 citations in Web of Science®
29 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:06 Jan 2012 14:20
Last Modified:05 Apr 2016 15:14
Publisher:Elsevier
ISSN:0021-9150
Publisher DOI:10.1016/j.atherosclerosis.2011.06.020
PubMed ID:21782178

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