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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53116

von Boehmer, L; Draenert, A; Jungraithmayr, W; Inci, I; Niklaus, S; Boehler, A; Hofer, M; Stahel, R; Soltermann, A; van den Broek, M; Weder, W; Knuth, A (2012). Immunosuppression and lung cancer of donor origin after bilateral lung transplantation. Lung Cancer, 76(1):118-122.

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Abstract

Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage 'Usual Interstitial Pneumonia' (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:04 Jan 2012 12:38
Last Modified:28 Nov 2013 03:15
Publisher:Elsevier
ISSN:0169-5002
Publisher DOI:10.1016/j.lungcan.2011.10.001
PubMed ID:22088939
Citations:Web of Science®. Times Cited: 3
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Scopus®. Citation Count: 2

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